Introduction and Aims: Drug addiction is considered as a disease and one of the four major crisis in the world (environmental crisis, poverty, nuclear threat and drugs) and this issue complex in Iran due to the presence of young population. This study was conducted to predict to based on personality factors (NEO).

Materials and Methods: The study was descriptive - correlational and the sample consisted of 220 undergraduate and graduate psychology students at Islamic Azad University in Sanandaj, in the academic year 2014-2015 who were selected using the convenience sampling method. Research tool was a five-factor model of personality NEO-FFI, and addiction potential scale of Ahvaz (LAP). Data analysis was conducted using SPSS-16 and LISERL software was utilized for path analysis.

: Regression analysis results showed that among the exogenous variables, extroversion and conscientiousness with of -0.15 and 0.37 had a direct significant effect on to addiction.

Conclusion: The results suggested that extroversion was a good predictor for students’ tendency to drug abuse. Therefore, education can help in the field of prevention of drug dependence.