Volume 5, Issue 1 (Summer 2019)                   SJNMP 2019, 5(1): 24-34 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ranjbar R, Jafari B, Naji S. Assessing the Antibiotic Resistance Pattern and Determining the Prevalence of Microbial Species in Children with Urinary Tract Infections Referring to Motahari Hospital in Urmia. SJNMP. 2019; 5 (1) :24-34
URL: http://sjnmp.muk.ac.ir/article-1-215-en.html
1- Ahar Branch, Islamic Azad University
2- Ahar Branch, Islamic Azad University , dr.behboud.jafari@gmail.com
3- Urmia University of Medical Sciences
Abstract:   (470 Views)
Background & Aim: Urinary tract infections are among the most prevalent diseases in children and can lead to serious complications if improperly treated with antibiotics. This study aimed to determine the bacteriological factors and resistance of children to urinary infection antibiotics.
Materials & Methods: This descriptive and cross-sectional research was performed on 160 children, who referred to Motahari Hospital in Urmia with a positive urine culture. The desired strains were recognized and identified using biochemical tests and differential culture media. In addition, antibiotic resistance pattern of the strains was determined by disc fusion method (Kirby-Bauer) as recommended by CLSI. Moreover, data analysis was performed using Chi-square, and P-value of less than 0.05 was considered significant. 
Results: Of 160 children assessed, 119 were female, and 41 were male. According to the results, the highest prevalence of urinary infection was related to the age range below two years. In addition, the most and least strains separated from urine cultures included E.coli (81.3%) and S.saprophyticus (1.9%), respectively. Furthermore, E.coli isolates had the most resistance to cotrimoxazole (64.6%), and nitrofurantoin was recognized as the most effective antibiotic with 90% sensitivity.
Conclusion: According to the results of the study, the use of nitrofurantoin, ciprofloxacin, and gentamicin antibiotics is recommended for primary treatment of urinary infections. Given the different frequency distribution of antibiotic resistance in various regions and periods, it is suggested that antibiotic resistance be assessed periodically to control infection.
Full-Text [PDF 613 kb]   (189 Downloads)    
Type of Study: Research | Subject: Special
Received: 2019/01/23 | Revised: 2019/09/3 | Accepted: 2019/04/25 | Published: 2019/06/9 | ePublished: 2019/06/9

1. Vélez Echeverri C, Serna-Higuita LM, Serrano AK, Ochoa-García C, Rojas Rosas L, Bedoya AM, et al. Profile resistance of pathogens causing urinary tract infection in the pediatric population, and antibiotic treatment response, at a University Hospital 2010-2011. J Colombia Médica. 2014;45:39-44.
2. Brandström P, Hansson S. Long-term, low-dose prophylaxis against urinary tract infections in young children. Pediatric Nephrology. 2015;30(3):425-32. [DOI:10.1007/s00467-014-2854-z]
3. Jafari-Sales A. Study of Antibiotic Resistance and Prevalence of bla-TEM gene in Klebsiella pneumoniae Strains isolated from Children with UTI in Tabriz Hospitals. Focus On Medical Sciences Journal. 2018; 4(1):9-13.
4. Jafari-Sales A, Rasi-Bonab F. Detection of the Antibiotic Resistance Pattern in Escherichia coli Isolated from Urinary Tract Infections in Tabriz City. J Mol Microbiol. 2017;1(1):1-3.
5. Sales A, Fathi R, Mobaiyen H. Molecular Study of the Prevalence of CTX-M1, CTX-M2, CTXM3 in Pseudomonas aeruginosa Isolated from Clinical Samples in Tabriz Town, Iran. Electronic J Biol. 2017;13(3):253- 9.
6. Sales AJ, Mobayyen H. Detection of the Antibiotic Resistance Pattern in Staphylococcus Aureus Isolated from Urinary Tract Infections in Marand City. Iranian Journal of Public Health. 2014;43(2):86.
7. Molaabaszadeh H, Hajisheikhzadeh B, Mollazadeh M, Eslami K, Mohammadzadeh Gheshlaghi N. Study of Sensibility and Antimicrobial Resistance in Escherichia coli Isolated from Urinary Tract Infection in Tabriz City. Journal of Fasa University of Medical Sciences. 2013;3(2):149-54. [In Persian]
8. Dizaji AS, Fathi R, Sales AJ. Molecular study of extended-spectrum beta-lactamase (TEM-1) gene in Escherichia Coli isolates collected from Ostad Alinasab Hospital in Tabriz Iran. Marmara Medical Journal. 2016;29(1):35-40. [DOI:10.5472/MMJoa.2901.06]
9. Jafari Sales A, Mobaiyen H. Frequency and resistance patterns in clinical isolates of Escherichia coli Extended Spectrum Beta Lactamase producing treatment Centers in Marand city, Iran. New Cellular and Molecular Biotechnology Journal. 2017;7(26):19-26.
10. Jafari Sales A, Mobaiyen H, Farshbafi Nezhad Zoghi J, Nezamdoost Shadbad N, Purabdollah Kaleybar V. Antimicrobial Resistance Pattern of Extended-Spectrum β-Lactamases (ESBLs) producing Escherichia coli Isolated from Clinical Samples in Tabriz city, Iran. Advances in Environmental Biology. 2014;8(16):179-82.
11. Winn W, Allen S, Janda W, Koneman E, Procop G, Schreckenberger P. and Woods, G. Koneman's Color Atlas and Textbook of Diagnostic Microbiology. 6th ed. New York: Lippincott Williams and Wilkins; 2006.
12. Fesharakinia A, Malekaneh M, Hooshyar H, Aval M, Gandomy-Sany F. The survey of bacterial etiology and their resistance to antibiotics of urinary tract infections in children of Birjand city. Journal of Birjand University of Medical Sciences. 2012;19(2):208-15. [In Persian]
13. Molazade A, Shahi A, Najafipour S, Mobasheri F, Norouzi F, Abdollahi Kheirabadi S, et al. Antibiotic Resistance Pattern of Bacteria Causing Urinary Tract Infections in Children of Fasa During the years 2012 and 2014. Journal of Fasa University of Medical Sciences. 2015;4(4):493-9. [In Persian]
14. Coban B, Ulku N, Kaplan H, Topal B, Erdogan H, Baskin E. Five-year assessment of causative agents and antibiotic resistances in urinary tract infections. Turk pediatri arsivi. 2014;49(2):124-9. [DOI:10.5152/tpa.2014.1505]
15. Clinical and Laboratory Standads Institute. M100-S27 Performance Standards for Antimicrobial Susceptibility Testing; Twenty-seven. Informational Supplement Clinical and Laboratory Standards Institute; 2017.
16. Ghorashi Z, Ghorashi S, Soltani-Ahari H, Nezami N. Demographic features and antibiotic resistance among children hospitalized for urinary tract infection in northwest Iran. Infection and drug resistance. 2011;4:171-6. [DOI:10.2147/IDR.S24171]
17. Mantadakis E, Tsalkidis A, Panopoulou M, Pagkalis S, Tripsianis G, Falagas ME, et al. Antimicrobial susceptibility of pediatric uropathogens in Thrace, Greece. Int J Nephrol Urol. 2011;43(2):549-55. [DOI:10.1007/s11255-010-9768-x]
18. Hanna-Wakim RH, Ghanem ST, El Helou MW, Khafaja SA, Shaker RA, Hassan SA, et al. Epidemiology and characteristics of urinary tract infections in children and adolescents. Front Cell Infect Microbiol. 2015;5(45): 1-10. [DOI:10.3389/fcimb.2015.00045]
19. Elder JS. Urinary tract infections. Nelson Textbook of Pediatrics. Philadelphia: Saunders; 2004.
20. Sharif M, Nouri S. The Frequency and Antibiotic Resistance of Urinary Tract Infection Organisms in Hospitalized Children. Shahid Beheshti Hospital. Kashan 2012-2013. Iran J Infect Dis Trop Med. 2014;19(65):47-51.
21. Alaei V, Salehzadeh F. The Clinical Manifestations and Antibiogram Results in Children with UTI. Journal of Ardabil University of Medical Sciences. 2008;8(3):274-80. [In Persian]
22. Eghbalian F, Yousefi M, R. Determining the frequency of the bacterial agents in urinary tract infections in hospitalized patients under 18 years old in Ekbatan hospital. J Army Uni Med Sci. 2005;3(3):635-9.
23. Ilić T, Gračan S, Arapović A, Čapkun V, Šubat-Dežulović M, Saraga M. Changes in bacterial resistance patterns in children with urinary tract infections on antimicrobial prophylaxis at University Hospital in Split. Medical science monitor: International Medical Journal of Experimental and Clinical Research. 2011;17(7):CR355. [DOI:10.12659/MSM.881845]
24. Gökçe İ, Çiçek N, Güven S, Altuntaş Ü, Bıyıklı N, Yıldız N, et al. Changes in Bacterial Resistance Patterns of Pediatric Urinary Tract Infections and Rationale for Empirical Antibiotic Therapy. Balkan Med J. 2017;34(5):432-5. [DOI:10.4274/balkanmedj.2015.1809]
25. Mirsoleymani SR, Salimi M, Shareghi Brojeni M, Ranjbar M, Mehtarpoor M. Bacterial Pathogens and Antimicrobial Resistance Patterns in Pediatric Urinary Tract Infections: A Four-Year Surveillance Study (2009-2012). International Journal of Pediatrics. 2014;2014:6-10. [DOI:10.1155/2014/126142]
26. Edlin RS, Shapiro DJ, Hersh AL, Copp HL. Antibiotic resistance patterns of outpatient pediatric urinary tract infections. The Journal of urology. 2013;190(1):222-7. [DOI:10.1016/j.juro.2013.01.069]
27. Rezaee MA, Abdinia B. Etiology and Antimicrobial Susceptibility Pattern of Pathogenic Bacteria in Children Subjected to UTI: A Referral Hospital-Based Study in Northwest of Iran. Medicine2015;94(39):e1606. [DOI:10.1097/MD.0000000000001606]
28. Heidary Z, Bandani E, Eftekhary M, Jafari AA. Virulence Genes Profile of Multidrug Resistant Pseudomonas aeruginosa Isolated from Iranian Children with UTIs. J Acta Medica Iranica. 2016:201-10.
29. Pobiega M, Maciag J, Pomorska-Wesolowska M, Chmielarczyk A, Romaniszyn D, Ziolkowski G, et al. Urinary tract infections caused by Pseudomonas aeruginosa among children in Southern Poland: Virulence factors and antibiotic resistance. J Pediatr Urol. 2016;12(1):36.e1-6. [DOI:10.1016/j.jpurol.2015.05.034]

Add your comments about this article : Your username or Email:

Send email to the article author

© 2020 All Rights Reserved | Scientific Journal of Nursing, Midwifery and Paramedical Faculty

Designed & Developed by : Yektaweb